(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate
(R)-N-FMOC-2-Fluorophenylalanine
CAS: 198545-46-9
Molecular Formula: C24H20FNO4
(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate - Names and Identifiers
| Name | (R)-N-FMOC-2-Fluorophenylalanine |
| Synonyms | Fmoc-D-2-F-phe Fmoc-D-2-Fluorophe Fmoc-D-Phe(2-F)-OH FMOC-D-2-FLUOROPHE FMOC-O-FLUORO-D-PHE-OH fmoc-d-2-fluorophenylalanine FMOC-D-2-FLUOROPHENYLALANINE Fmoc-2-Fluoro-D-phenylalanine (R)-N-FMOC-2-Fluorophenylalanine D-2-Fluorophenylalanine, FMOC protected FMOC-(R)-2-AMINO-3-(2'-FLUOROPHENYL)PROPANOIC ACID N-(9-Fluorenylmethoxycarbonyl)-2-fluorophenyl-D-alanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-fluoro-D-phenylalanine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-fluoro-L-phenylalanine (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(2-fluorophenyl)propanoate (2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate |
| CAS | 198545-46-9 |
| InChI | InChI=1/C24H20FNO4/c25-21-12-6-1-7-15(21)13-22(23(27)28)26-24(29)30-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,26,29)(H,27,28)/t22-/m1/s1 |
(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate - Physico-chemical Properties
| Molecular Formula | C24H20FNO4 |
| Molar Mass | 405.42 |
| Density | 1.2642 (estimate) |
| Melting Point | 145.3 °C |
| Boling Point | 620.3±55.0 °C(Predicted) |
| Specific Rotation(α) | 44 º (c=1,DMF) |
| Flash Point | 328.9°C |
| Vapor Presure | 3.03E-16mmHg at 25°C |
| Appearance | grayish white to beige crystalline powder |
| pKa | 3.76±0.11(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.622 |
(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| Hazard Note | Harmful |
(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate - Introduction
(R)-N-FMOC-2-Fluorophenylalanine is an amino acid derivative with the following properties:
Nature:
-Appearance: White solid
-Molecular formula: C17H16FNO4
-Molecular weight: 331.31g/mol
-Melting Point: 157-160 ℃
-Solubility: Soluble in organic solvents (such as dimethyl sulfoxide), insoluble in water
Use:
- (R)-N-FMOC-2-Fluorophenylalanine is commonly used in peptide synthesis in solid phase synthesis
-It can be used as a protected amino acid and can be used to synthesize polypeptides and proteins with D-2-fluorophenylalanine residues
-It has important application value in drug research and biochemical research
Method:
Generally, the preparation method of (R)-N-FMOC-2-Fluorophenylalanine is as follows:
1. First prepare Fmoc-D-2-aminopropionic acid
2. Acylation of Fmoc-D-2-aminopropionic acid with 2-fluoropropionic acid to obtain the target product (R)-N-FMOC-2-Fluorophenylalanine
Safety Information:
- (R)-N-FMOC-2-Fluorophenylalanine are commonly used reagents in laboratories, but they may be harmful to the human body, so they must follow safe operating procedures when using them
-Wear appropriate protective equipment such as gloves, goggles and lab coats during operation
-Avoid contact with skin and eyes. If contact occurs, rinse with water immediately and seek medical help
-During storage, it should be sealed and stored in a dry and cool place, away from fire and oxidizing agents
Nature:
-Appearance: White solid
-Molecular formula: C17H16FNO4
-Molecular weight: 331.31g/mol
-Melting Point: 157-160 ℃
-Solubility: Soluble in organic solvents (such as dimethyl sulfoxide), insoluble in water
Use:
- (R)-N-FMOC-2-Fluorophenylalanine is commonly used in peptide synthesis in solid phase synthesis
-It can be used as a protected amino acid and can be used to synthesize polypeptides and proteins with D-2-fluorophenylalanine residues
-It has important application value in drug research and biochemical research
Method:
Generally, the preparation method of (R)-N-FMOC-2-Fluorophenylalanine is as follows:
1. First prepare Fmoc-D-2-aminopropionic acid
2. Acylation of Fmoc-D-2-aminopropionic acid with 2-fluoropropionic acid to obtain the target product (R)-N-FMOC-2-Fluorophenylalanine
Safety Information:
- (R)-N-FMOC-2-Fluorophenylalanine are commonly used reagents in laboratories, but they may be harmful to the human body, so they must follow safe operating procedures when using them
-Wear appropriate protective equipment such as gloves, goggles and lab coats during operation
-Avoid contact with skin and eyes. If contact occurs, rinse with water immediately and seek medical help
-During storage, it should be sealed and stored in a dry and cool place, away from fire and oxidizing agents
Last Update：2024-04-09 20:49:11
![(2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(2-fluorophenyl)propanoate](http://res.chembk.com/assets/str/2d/1/19/198545-46-9.png)
Supplier List
Product Name: FMOC-D-2-Fluorophe Visit Supplier Webpage Request for quotation
CAS: 198545-46-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 198545-46-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: FMOC-D-2-Fluorophe Visit Supplier Webpage Request for quotation
CAS: 198545-46-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 198545-46-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History